Capsaicin
Hot-pepper alkaloid that activates TRPV1 — surface-level flushing and burning sensation, contraindicated in active rosacea.
What it does
Capsaicin binds the TRPV1 receptor on sensory neurons, triggering vasodilation, warmth, and the burn that gave chili peppers their reputation. In rosacea, the same vasoreactivity that drives flushing episodes makes capsaicin a documented topical trigger — even at sub-clinical levels found in pepper-extract cosmetics. Therapeutic capsaicin patches exist for neuropathic pain at concentrations far higher than cosmetic use; skincare uses are aesthetic / 'lip plumper' framings the rosacea-active user should avoid.
The evidence, graded
Graded per the methodology: strong · moderate · emerging · expert consensus. A weak source on a strong claim gets the weaker label.
Also known as
chili extract