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Ca

Capsaicin

Capsicum Frutescens Fruit Extract

Hot-pepper alkaloid that activates TRPV1 — surface-level flushing and burning sensation, contraindicated in active rosacea.

What it does

Capsaicin binds the TRPV1 receptor on sensory neurons, triggering vasodilation, warmth, and the burn that gave chili peppers their reputation. In rosacea, the TRPV1 pathway that drives flushing is the same one capsaicin activates, which is why rosacea guidance lists capsaicin-containing topicals among the ingredients to avoid during a flare. Therapeutic capsaicin patches exist for neuropathic pain at concentrations far higher than cosmetic use; skincare uses are aesthetic / 'lip plumper' framings the rosacea-active user should avoid.

The evidence, graded

expert consensusDuring an active rosacea flare, ingredients that trigger TRPV1 or vasodilation channels (capsaicin, cinnamaldehyde, peppermint oil, menthol) reliably worsen flushing and burning in most patients. Avoid them when skin is flaring; they can sometimes be tolerated when the condition is well-controlled.Steinhoff 2011 · Journal of Investigative Dermatology Symposium Proceedings ↗

Graded per the methodology: strong · moderate · emerging · expert consensus. A weak source on a strong claim gets the weaker label.

Also known as

chili extract

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