Sy
Syn-Ake
Dipeptide Diaminobutyroyl Benzylamide DiacetateActive
Synthetic peptide modeled on snake-venom waglerin. Marketed as a topical 'expression-line relaxer.'
What it does
Syn-Ake is a synthetic peptide marketed as a topical alternative to neuromodulator injections. The mechanistic story (acetylcholine receptor modulation) is interesting; the topical efficacy evidence is weak — the molecular size doesn't penetrate to the muscle layer. Realistic expectation: a mild surface-smoothing effect comparable to other peptide ingredients, not a substitute for neuromodulator treatments.
The evidence, graded
strongMost cosmetic peptides (Matrixyl, copper peptides, palmitoyl tripeptide-1) show measurable firmness or elasticity changes in 8-12 weeks of consistent twice-daily use. Visible benefits are typically subtle compared to retinoids.Robinson 2005 · International Journal of Cosmetic Science ↗
Graded per the methodology: strong · moderate · emerging · expert consensus. A weak source on a strong claim gets the weaker label.
Also known as
dipeptide diaminobutyroyl benzylamide diacetate
Pairs worth knowing
This page is public and indexed on purpose (unlike profiles and drops, which are unlisted) — it’s the citation behind shared ingredient cards, and it should be findable.
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