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Adenosine
Adenosine
A fine-lines ingredient — one placebo-controlled trial measured smoother eye-area skin by week 3, still there at 8 weeks.
What it does
Adenosine is a molecule your cells already use for energy and signaling. On skin it’s studied for fine lines. Only one trial has tested it, in women aged 45 to 65, so its result hasn’t been repeated yet.
The evidence, graded
strongIn one blind, randomized, placebo-controlled trial, 126 women aged 45 to 65 applied an adenosine cream or film around the eyes for 2 months. Skin there was significantly smoother at the first check, week 3, and still smoother at week 8. The cream also improved frown lines. The trial gives no effect size and ended at 8 weeks, so it cannot say how large the change is or what happens after 2 months.Abella 2006 · International Journal of Cosmetic Science ↗
Graded per the methodology: strong · moderate · emerging · expert consensus. A weak source on a strong claim gets the weaker label.
Pairs worth knowing
Browse all 1238 ingredients — grouped by what they do, each with whatever evidence we can cite.
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