Ma
Matrixyl 3000
Active
A trade-name blend of two signaling peptides for fine lines and firmness. The maker’s studies show modest effects over 8–12 weeks.
What it does
It’s a trade name for a blend of two signaling peptides, sold for fine lines and firmness. The maker’s studies show modest effects over 8–12 weeks; independent evidence is weaker than the marketing suggests.
The evidence, graded
strongPal-KTTKS (Matrixyl) has the most trials. A placebo-controlled study applied 0.005% around one eye twice daily for 28 days: fold depth down 18%, fold thickness down 37%, by profilometry. A 12-week split-face trial of 3 ppm reduced wrinkles and fine lines, and a four-month study improved roughness and wrinkle depth. Copper peptide (GHK-Cu) reaches Drop through a review; its placebo-controlled studies all ran 12 weeks, and its one earlier measurement is collagen in thigh biopsies at a month.Robinson 2005 · International Journal of Cosmetic Science ↗
emergingFine together — peptides (short chains of amino acids) such as palmitoyl tripeptide-1 are thought to work differently from retinol.Mukherjee 2006 · Clinical Interventions in Aging ↗
Graded per the methodology: strong · moderate · emerging · expert consensus. A weak source on a strong claim gets the weaker label.
Pairs worth knowing
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