Pa
Palmitoyl Oligopeptide
Palmitoyl OligopeptideActive
A retired name for palmitoyl tripeptide-1 or palmitoyl hexapeptide-12; evidence on what it does for skin is limited.
What it does
It’s a short chain of amino acids joined to palmitic acid, a fatty acid. Products use it to condition skin.
The evidence, graded
expert consensusThe ingredient dictionary retired the name palmitoyl oligopeptide in 2013 because it was vague: it could mean either of two small peptides joined to palmitic acid. They are now named palmitoyl tripeptide-1 (the Gly-His-Lys sequence) and palmitoyl hexapeptide-12 (Val-Gly-Val-Ala-Pro-Gly). US safety reviewers (2018) judged both safe as used; these peptides are used mostly to condition skin, typically at under 10 ppm.Johnson 2018 · International Journal of Toxicology ↗
Graded per the methodology: strong · moderate · emerging · expert consensus. A weak source on a strong claim gets the weaker label.
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