Pa
Palmitoyl Tetrapeptide-7
Palmitoyl Tetrapeptide-7Active
A peptide sold for calming and for fine lines, mostly on the maker’s studies.
What it does
It’s a small peptide with a fatty tail. The maker’s studies say it calms an inflammation signal and helps fine lines. It’s most often paired with palmitoyl tripeptide-1, and the evidence comes mostly from the maker.
The evidence, graded
strongPal-KTTKS (Matrixyl) has the most trials. A placebo-controlled study applied 0.005% around one eye twice daily for 28 days: fold depth down 18%, fold thickness down 37%, by profilometry. A 12-week split-face trial of 3 ppm reduced wrinkles and fine lines, and a four-month study improved roughness and wrinkle depth. Copper peptide (GHK-Cu) reaches Drop through a review; its placebo-controlled studies all ran 12 weeks, and its one earlier measurement is collagen in thigh biopsies at a month.Robinson 2005 · International Journal of Cosmetic Science ↗
expert consensusUS safety reviewers (2018) assessed a group of skin-conditioning peptides, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7 among them. Products typically hold under 10 parts per million. In repeat patch tests on people, mixtures with 1,000 ppm tripeptide-1 or 500 ppm tetrapeptide-7 didn’t irritate or cause allergy. Given the low amounts and clean tests, they judged both safe as used. The verdict covers only the GHK form of tripeptide-1 and the GQPR form of tetrapeptide-7.Johnson 2018 · International Journal of Toxicology ↗
emergingFine together — peptides (short chains of amino acids) such as palmitoyl tripeptide-1 are thought to work differently from retinol.Mukherjee 2006 · Clinical Interventions in Aging ↗
emergingFine together for your skin; the only question is whether the acid's low pH makes the peptide less effective. To rule it out, use the acid in the morning and the peptide at night. The only stability test here found the peptide intact down to pH 4.5; a vitamin C or AHA layer sits below that, which nobody has tested, and no study Drop has read applied the two in one step.Errante 2020 · Frontiers in Chemistry ↗
Graded per the methodology: strong · moderate · emerging · expert consensus. A weak source on a strong claim gets the weaker label.
Pairs worth knowing
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