Skincare without the upsell.
Er

Ergothioneine

ErgothioneineAntioxidant

Naturally occurring amino acid antioxidant that the body actively accumulates via a dedicated transporter; increasingly used in premium antioxidant serums.

What it does

Ergothioneine is an amino acid found in mushrooms, legumes, and oat bran. The body uses a special carrier protein (OCTN1) to take it up from food. This active uptake makes it unusual among antioxidants. In skin, it helps guard against free radical damage from UV exposure. Lab studies support its antioxidant action. Clinical trials on topical use for aging concerns are still emerging. Used in antioxidant serums and face creams. Well-tolerated at typical skin care amounts.

Also known as

ergothionine, thiohistidine betaine, egt

Pairs worth knowing

Browse all 706 ingredients — grouped by what they do, each with whatever evidence we can cite.

This page is public so a shared ingredient card always has its sources behind it — and so you can check them without an account.
Want more like this?
Every evidence-based flag cites its source, Drop tells you when your routine is complete, and it helps you simplify — instead of selling you more. The app launches on iOS and Android in October 2026. Rate my routine works today at /rate — no sign-in.