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Matrixyl
Palmitoyl Pentapeptide-4Active
A brand-name signal peptide sold for collagen support — in one 4-month trial it reduced wrinkle depth versus a plain cream.
What it does
Matrixyl is a trade name for a family of peptides sold to support collagen. In a four-month trial, 49 women who used the original version twice a day had less roughness and smaller, shallower wrinkles than with a plain cream. Results for many peptides are sparse, and it hasn’t been compared with vitamin C or retinoids.
The evidence, graded
emergingFine together — peptides (short chains of amino acids) such as palmitoyl tripeptide-1 are thought to work differently from retinol.Mukherjee 2006 · Clinical Interventions in Aging ↗
emergingFine together for your skin; the only question is whether the acid's low pH makes the peptide less effective. To rule it out, use the acid in the morning and the peptide at night. The only stability test here found the peptide intact down to pH 4.5; a vitamin C or AHA layer sits below that, which nobody has tested, and no study Drop has read applied the two in one step.Errante 2020 · Frontiers in Chemistry ↗
Graded per the methodology: strong · moderate · emerging · expert consensus. A weak source on a strong claim gets the weaker label.
Also known as
pal-kttks
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