Re
Resveratrol
ResveratrolAntioxidant
A grape-skin antioxidant. Its trials are small: as a cream alone it raised skin oil, and a pilot found less acne.
What it does
It’s an antioxidant found in grape skins. On skin, its trials are small and mixed: wrinkles improved only when women also took it as a pill.
The evidence, graded
strongRao et al. (2025) randomized women over 40 (134 enrolled, 122 completed) to 75 mg oral and/or 1.5% topical trans-resveratrol or placebo, twice daily for 8 weeks. Wrinkle scores fell significantly in the oral-plus-topical group versus placebo. Both topical groups had significantly higher U-zone sebum than the placebo-cream groups, and no other skin measure differed. Two authors work for Lallemand Bio-Ingredients, which markets these ingredients as supplements.Rao 2025 · Frontiers in Aging ↗
strongFabbrocini et al. (2011): 20 people with acne applied a resveratrol gel to one side of the face and the plain gel to the other for 60 days, in a single-blind pilot study. The acne grading score fell by 53.75% on the resveratrol side and 6.10% on the plain-gel side. The authors call it a starting point for testing in a larger group.Fabbrocini 2011 · American Journal of Clinical Dermatology ↗
debatedA 2025 review of resveratrol in skin disease reports robust evidence from animal studies for faster wound healing, less inflammation and tumor suppression. It calls the human trial data nascent yet promising, with good tolerability and early signs of benefit. Poor absorption into the body has held it back, and the review says new delivery systems for skin are improving that. It calls for large, well-designed trials.Cui 2025 · Clinical, cosmetic and investigational dermatology ↗
Graded per the methodology: strong · moderate · emerging · expert consensus. A weak source on a strong claim gets the weaker label.
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