Tr
Trifarotene
TrifaroteneActive
Prescription fourth-generation retinoid for acne, selective for the RAR-gamma receptor in skin.
What it does
Trifarotene is a newer topical retinoid, available by prescription at 0.005% for acne on the face, chest and back. It works on skin-cell turnover like the rest of its class, needs a slow ramp-up, and can irritate. The class-wide pregnancy caution covers it too.
The evidence, graded
strongNo topical retinoid is recommended in pregnancy. The class covers tretinoin, adapalene, tazarotene, trifarotene, retinol, retinaldehyde, retinyl palmitate and hydroxypinacolone retinoate. Studies of accidental exposure, mostly to tretinoin and adapalene early in pregnancy, are reassuring. They are not strong enough to recommend any retinoid in pregnancy. The caution extends to the other retinoids as a class-effect. Oral isotretinoin is a separate case, with an absolute contraindication.Kaplan 2015 · British Journal of Dermatology ↗
Graded per the methodology: strong · moderate · emerging · expert consensus. A weak source on a strong claim gets the weaker label.
Also known as
aklief
Pairs worth knowing
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