Tr
Trifarotene
TrifaroteneActive
Prescription fourth-generation retinoid for acne, selective for the RAR-gamma receptor in skin.
What it does
Trifarotene is a newer topical retinoid, available by prescription at 0.005% for acne on the face, chest and back. It works on skin-cell turnover like the rest of its class, needs a slow ramp-up, and can irritate. The class-wide pregnancy caution covers it too.
The evidence, graded
strongNo topical retinoid is recommended in pregnancy. The class covers tretinoin, adapalene, tazarotene, trifarotene, retinol, retinaldehyde, retinyl palmitate and hydroxypinacolone retinoate. Direct human data exist mainly for tretinoin and adapalene. The caution extends to the rest as a class-effect. Data on accidental exposure reassure, but are not strong enough to recommend any retinoid here. Oral isotretinoin is a separate case, with an absolute contraindication.Kaplan 2015 · British Journal of Dermatology ↗
Graded per the methodology: strong · moderate · emerging · expert consensus. A weak source on a strong claim gets the weaker label.
Also known as
aklief
Pairs worth knowing
This page is public and indexed on purpose (unlike profiles and drops, which are unlisted) — it’s the citation behind shared ingredient cards, and it should be findable.
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