Gl
Gluconolactone
GluconolactoneExfoliant
Polyhydroxy acid (PHA). Same chemical-exfoliation principle as AHAs, with a much gentler skin-tolerance profile.
What it does
Gluconolactone is a larger molecule than glycolic or lactic acid, so it penetrates the skin more slowly. The result is similar surface-level exfoliation with markedly less stinging, redness, or photosensitivity. Often the first acid recommended for sensitive skin, rosacea-prone skin, or compromised-barrier states. Pairs without compounding irritation alongside niacinamide, peptides, and (for tolerated users) a low-percent retinoid.
The evidence, graded
strongAHAs (glycolic, lactic, mandelic) need an acidic pH (typically 3.5-4) to deliver advertised exfoliation. Products with neutral or partially neutralized pH still hydrate but won't drive meaningful keratolysis.Smith 1996 · Journal of the American Academy of Dermatology ↗
Graded per the methodology: strong · moderate · emerging · expert consensus. A weak source on a strong claim gets the weaker label.
Also known as
pha, polyhydroxy acid
Pairs worth knowing
This page is public and indexed on purpose (unlike profiles and drops, which are unlisted) — it’s the citation behind shared ingredient cards, and it should be findable.
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