Ma
Madecassoside
MadecassosideSoothing
A compound pulled out of centella (cica). It’s been tested only in creams with other ingredients, after laser and on aged skin.
What it does
It’s one of the main compounds in centella (cica). Its two trials both mixed it with other ingredients, so neither shows what it does on its own.
The evidence, graded
strongLueangarun et al. (2019): in a double-blinded, split-face trial, 20 people had fractional CO2 laser and used a moisturizer with 5% panthenol, madecassoside and copper-zinc-manganese on one side and 0.02% triamcinolone acetonide cream on the other for 7 days. Both creams significantly reduced swelling, redness, crusting and scaling in 5 to 7 days, with no statistically significant difference between them.Lueangarun 2019 · Journal of Cosmetic Dermatology ↗
strongHaftek et al. (2008): a randomized double-blind study on the photoaged skin of 20 women tested 5% vitamin C with 0.1% madecassoside applied to the skin. After 6 months the clinical score improved significantly for deep and superficial wrinkles, suppleness, firmness, roughness and skin hydration. Two-thirds of the subjects showed an improvement.Haftek 2008 · Experimental Dermatology ↗
Graded per the methodology: strong · moderate · emerging · expert consensus. A weak source on a strong claim gets the weaker label.
Also known as
centella triterpenoid
Pairs worth knowing
Browse all 1238 ingredients — grouped by what they do, each with whatever evidence we can cite.
This page is public so a shared ingredient card always has its sources behind it — and so you can check them without an account.
Want more like this?
Every evidence-based flag cites its source, Drop tells you when your routine is complete, and it helps you simplify — instead of selling you more. The app launches on iOS and Android in October 2026. Rate my routine works today at /rate — no sign-in.